Ok, I think I understand what you mean now. You want to use an acknex rendering engine for a strategy game with loads and loads of players.
Yes, that is possible.

Depending on the number of players though, you might need to distribute them across multiple servers. I advice you to do a stress-test (lots of http requests that require the server to check something in the database, calculate something and then send the answer back from multiple clients). Then see how long it usually takes to respond.

Otherwise you might just be wasting lots of your time if you find out at the end that the database searching or sending is too slow.