If you are going to be working with a 2D engine - pick up a book (or grab one of the Loomis books from online http://www.saveloomis.org/ and learn perspective techniques. He does a great job introducing things to you - and after that, just play with it a bit.

With a real 2D engine you can do some fun things with 2 and 3 point perspective that are nearly impossible with a 3D engine. Definately would help with the style of game you are working as well (allow you to get those comic book camera angles).